The Kurnakov test, also known as Kurnakov’s reaction, is a chemical test that The test was devised by Soviet chemist Nikolai Semenovich Kurnakov. I’m trying to answer this question: However, I don’t fully understand the exact synthesis of the thiourea complexes. For one, I don’t understand. of substituted pyrimidines and their products from thiourea in Kurnakov’s reaction react with thiourea (tu) to give different products (Kurnakov’s test).

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A chemical reaction that he pioneered, known as the Kurnakov testis still used to differentiate cis from trans isomers of divalent platinum and is his best-known contribution to coordination chemistry. He postulated that the trans effects of atoms are inversely proportional to their metallic character, i.

Kurnakov test

In that same year he became Head Chemist of the Platinum Institute. Views Read Edit View history.

As such, his name is associated with a ournakov and advanced method for the purification of platinum, its separation in highest purity, the preparation of pure osmium, a method for extracting platinum metals from low grade ores, the development of a series of analytical methods for noble metals, and the solution of lurnakov other critical industrial problems.

Journal of Chemical Education. A mineral was named kurnakovite in his honor, kong, Pi-Chang, Rochon, F.

Canadian Journal of Chemistry. Academician of the Academy of Sciences of the U. The Kurnakov test is sometimes used to detect transplatin in samples of the drug cisplatin. Synthesis of cisplatin using the trans effect. He published his first paper on alum crystallization and sodium thioantimoniate inin the same year he graduated as a mining engineer.

The scientific work of this trip became his Ph.

In his later years, he focused his work on kurnamov chemistry and platinum production. Cisplatin is one of the most emetogenic chemotherapy agents, but this is managed with prophylactic antiemetics e. The ototoxicity of both the aminoglycosides and cisplatin may be related to their ability to bind to melanin in the stria vascularis of the inner ear or the generation of reactive oxygen species.


Interaction with cellular proteins, particularly HMG domain proteins, has also been advanced as a mechanism of interfering with mitosis, although this is probably not its primary method of action. Neurotoxicity nerve damage can be anticipated by performing nerve conduction studies before and after treatment.

Member feedback about Ulmas Mirsaidovich Mirsaidov: Stalin suppressed all opposition to his rule, committed the state ideology to Marxism—Leninism.

Cisplatin can cause hypomagnesaemia, hypokalaemia and hypocalcaemia. There was no secondary school in Arzamas at that time and Dobrokhotov was sent to Nizhny Novgorod, where in he entered the Realschule. Aprepitant combined with ondansetron and dexamethasone has been shown to be better for highly emetogenic chemotherapy than just ondansetron and dexamethasone.

The Kurnakov test is sometimes used to detect transplatin in samples of the drug cisplatin. Almost every student of organic chemistry knows that most substitution reactions do not occur in a random manner, and in a similar manner, substitution reactions among coordination compounds are not random. Chemists Revolvy Brain revolvybrain. Enter your email address to receive our quarterly alerts. As a result, the country underwent a period of rapid industrialization and collectivization which laid the foundation for its victory in World War II and postwar dominance of Eastern Europe.

Il’ya Il’ich Chernyaev’s Research on the Platinum Metals | Johnson Matthey Technology Review

On 25 DecemberGorbachev resigned and the twelve constituent republics emerged from the dissolution of the Soviet Union as independent post-Soviet states 2. Canadian Journal of Chemistry. Kauffman, Platinum Metals Rev. He was made a Corresponding Member of the U. It is attributed to effects and it is most fest in square planar complexes.


The test is still used to assay samples of the drug cisplatinbut it is mainly of pedagogical interest, as it twst the trans effect.

Nikolai Semenovich Kurnakov

The trans effect in metal complexes, the cis- and trans-effects of ligands. YouTube Videos [show more]. Upon administration, a chloride ligand undergoes slow displacement with water an aqua ligand molecules, in a process termed aquation. Benjamin, New York,p. The test is still used to assay samples of the drug cisplatin, but it is mainly of pedagogical interest, as it illustrates the trans effect.

The test was devised by Soviet chemist Nikolai Semenovich Kurnakov. InKurnakov became professor of chemistry for his work on the reactions of cis- and trans- platinum complexes with thiourea. Retrieved from ” https: Transplatin, the trans diastereomer of cisplatin, has formula trans -[PtCl 2 NH 3 2 ] and does not exhibit a comparably useful pharmacological effect. He then worked for years at the mining institute, mostly on the formation of salts and potash deposits and mining and benefication of salt.

Detailed studies on its molecular mechanism of action, using a variety of spectrocopic methods including X-ray, NMR spectroscopy, and other physico-chemical methods, revealed its ability to form irreversible crosslinks with bases in DNA.

He published his first paper on alum crystallization and sodium thioantimoniate in Wikipedia is powered by MediaWikian open source wiki engine. In hot aqueous solution, the cis compound reacts with aqueous thiourea tu kurnakvo give a deeper yellow solution from which yellow needles of [Pt tu ]Cl chloride deposit on kurnakob.