EUDRAGIT L30 D55 PDF

Evonik’s EUDRAGIT® polymers enable gastrointestinal tract targeting, along with improved protective, sustained-release and solubility performance. Copolymer, EUDRAGIT L 30 D is the aqueous dispersion of anionic polymers with methacrylic acid as a functional group. Physical properties: It is a. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Different weight gains of acrylic polymer were applied onto the pellets and evaluated.

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To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below. The coated pellets were kept in glass dishes and stored in a closed container at ambient temperature. Drug turns brown when comes in contact with air due to oxidation eudrafit phenolic group in benzene moiety, therefore 0.

Surface morphology of developed pellets were investigated under scanning electron microscope which revealed a smooth and spherical surface fig. The dispersion was stirred slowly to avoid the production of air bubbles.

It was seen that the drug release from the coated pellets depended on the pH of the dissolution medium as well as weights applied. Similarly pellets were also prepared with varying amount of granulating liquid, higher granulating liquid content resulted in harder pellets that could be a factor in delaying dissolution behavior.

It is a milky-white liquid of low viscosity with a faint characteristic odor. A speed of rpm was selected as optimized speed for the production of spherical and smooth surface pellets. The pellets were fluidized for 15 min. The wet mass was extruded with a Fauji Paudal granulator through a 1. Login to see your most recently viewed materials here. Subscribe to our Newsletter All our latest content delivered to your inbox. The extrudates was spheronized for 2 min in Fauji Paudal mearumerizer [ 7 ].

Twenty grams of pellets were poured gradually through a funnel into a 50 ml graduated cylinder, tapped 50 times using USP density test apparatus. Coating was applied by fluidized bed coater under parameters listed in Table 2.

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Subcoating of pellets is done to improve acid resistance of entericcoated dosage forms. Pellets were then transferred from the fluidized bed and the residual powder was removed prior to recording the final weight. Acrylates Copolymer Information provided by Evonik. A burst effect has so far not been reported with multiparticulate systems. An over coat was added to Sod PAS pellets that were coated with Eudragit L 30 D to prevent the sticking of the pellets during dissolution studies and storage.

Fluidized bed coater performed enteric coating. Data sheets for overmetals, plastics, ceramics, and composites. Acrylates Copolymer Information provided by Evonik Vendors: Pellets were coated with Eudragit L 30 D using fluidized bed processor. Average pellet size was determined by sieve analysis and found to be A peristalsis pump was used to deliver the coating dispersion to the spray nozzle. Ten percent aqueous solution of PEG 8.

A magnetic stirrer was used to continually mix the coating dispersion during the coating process to prevent sedimentation.

Morphological characteristics of developed pellets were also investigated by scanning electron microscopy and found to be smooth and spherical. Please contact us at webmaster matweb. In vitro release of sod PAS from coated pellets with different weight gain. We appreciate your input. Following materials were used for the development of multiparticulate system: Therefore when coating solution was sprayed on to the pellets, it solubilized the drug and pulled it into the film as a result of which correct dissolution profile was not obtained.

Sod PAS containing pellets mesh were coated with the aqueous coating dispersion in a fluid-bed coater. Poly methacrylic acid-co-ethyl acrylate 1: The friability of the uncoated pellets was determined by inserting 20 g sample of pellets inside a fluidized bed unit fitted with a Wurster insert.

Eudragit has a tendency to swell and form a lump in the basket due to which pellets were not properly exposed to the dissolution media. Glcerylmonostearate dispersion in methylene chloride was used for this purpose and was prepared by adding the powder to the solvent.

The effect of the polymethacrylate copolymer coating system and weight gain applied were evaluated for in vitro release in order to obtain delayed release.

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Property Data This page displays only the text of a material data sheet. Eudraggit here to view all the property values for this datasheet as they were originally entered into MatWeb. Optimized process conditions and parameters are listed in Table 1. Effect of different weight gain of acrylate polymer was evaluated by in vitro dissolution studies.

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The focus of the present study was to produce pellets as multi-particulate delivery system, because of its eidragit over monolithic dosage forms. Or if you don’t have an account with us yet, then click here to register. Please read our License Agreement regarding materials data and our Privacy Policy.

Parameters Value Spheronization speed rpm Spheronization load g Spheronization time 2 minute Amount of granulation liquid 65 ml Screen used 1.

Shaker eudrafit shaken for 20 min, particles retained on different sieves were collected and average pellets size was determined. All the reagents and solvents used were of analytical grades. MatWeb is intended for personal, non-commercial use. Different weight gains of acrylic polymer were applied onto the pellets and evaluated for in vitro dissolution behavior in 0.

EUDRAGIT® L 30 D Spray Suspension Formulation

Pellet size and size distribution was determined for coated pellets with different weight gain and it was found to be narrow in distribution fig. The aim of this study was to develop an enteric coated multiparticulate formulation, which ensures the protection of sod PAS in acidic environment and delivers the drug in intestinal region.

The fluid bed coating is currently a widely used technique because it allows, among the other applications, crystals or granules to be coated with a variety of available polymers to fudragit gastroresistant or controlled release system.

Subcoating has been proposed by many scientists [ 4 – 6 ] as a method to improve the acid resistance for enteric coated dosage forms.